1098-2744/asset/MC_left.gif?v=1&s=a556feb61d2679d84abfca84c413171f17d27f7e)
1098-2744/asset/MC_centre.gif?v=1&s=bb43877f0d0e0160867f47a54d7bcb7e5c431bb0)
1098-2744/asset/MC_right.gif?v=1&s=027d4f6882bb87a19b63005e29bd7ceaf329c50f)
Brief Communication
Cross reactivity between many anti-human antibodies for their hamster homologs provide the tools to study the signal transduction pathway activated by asbestos and SV40 in the malignant mesothelioma model
Article first published online: 30 APR 2006
DOI: 10.1002/mc.20200
Copyright © 2006 Wiley-Liss, Inc.
Additional Information
How to Cite
Kroczynska, B. and Carbone, M. (2006), Cross reactivity between many anti-human antibodies for their hamster homologs provide the tools to study the signal transduction pathway activated by asbestos and SV40 in the malignant mesothelioma model. Molecular Carcinogenesis, 45: 537–542. doi: 10.1002/mc.20200
Publication History
- Issue published online: 11 JUN 2006
- Article first published online: 30 APR 2006
- Manuscript Accepted: 9 JAN 2006
- Manuscript Revised: 5 JAN 2006
- Manuscript Received: 6 DEC 2005
- Abstract
- Article
- References
- Cited By
Keywords:
- asbestos;
- mesothelial cells;
- mesothelioma;
- SV40
Abstract
The aim of this study was to test the possibility of using human antibodies to study the pathogenic mechanism of SV40 and asbestos in a hamster mesothelioma model. The cellular lysates from human and hamster primary mesothelial cells were tested by Western blot analysis. All of the antibodies we tested (HGF, Notch, VEGF, Sp1, p53, PP2A, p-ERK1, p-c-jun, Fra1, Fra2, MMP1, MMP9, NFκB p65, IκB, GAPDH) cross-reacted with their hamster counterparts. These data indicate that hamster mesothelioma model and more in general hamster experimental model, can be used for functional studies because many mouse, rabbit, and goat monoclonal antibodies prepared against human antigens cross-react with their hamster counterparts. © 2006 Wiley-Liss, Inc.