In Perspective Review
NF-κB and cancer: Mechanisms and targets
Article first published online: 3 MAY 2006
Copyright © 2006 Wiley-Liss, Inc.
Special Issue: Targeting Carcinogenesis: Transduction, Transcription, and Translation, Rochester, Minnesota, October 6–7, 2005
Volume 45, Issue 6, pages 355–361, June 2006
How to Cite
Karin, M. (2006), NF-κB and cancer: Mechanisms and targets. Mol. Carcinog., 45: 355–361. doi: 10.1002/mc.20217
- Issue published online: 16 MAY 2006
- Article first published online: 3 MAY 2006
- Manuscript Accepted: 13 MAR 2006
- Manuscript Received: 10 MAR 2006
In addition to being a central coordinator of immune responses, NF-κB signaling also plays a critical role in cancer development and progression and it may determine the response to therapy. NF-κB activation was shown to provide a critical mechanistic link between inflammation and cancer and is a major factor that controls the ability of both preneoplastic and malignant cells to resist apoptosis-based tumor surveillance mechanisms. NF-κB may also be involved in regulation of tumor angiogenesis and invasiveness. Importantly, NF-κB and the signaling pathways that mediate its activation have become attractive targets for development of new chemopreventive and chemotherapeutic approaches. © 2006 Wiley-Liss, Inc.