Get access
Advertisement

NF-κB and cancer: Mechanisms and targets

Authors

  • Michael Karin

    Corresponding author
    1. Laboratory of Gene Regulation and Signal Transduction, Department of Pharmacology, University of California San Diego, School of Medicine, La Jolla, California
    • Laboratory of Gene Regulation and Signal Transduction, Department of Pharmacology, University of California San Diego, School of Medicine, 9500 Gilman Drive, La Jolla, CA 92093.
    Search for more papers by this author

Abstract

In addition to being a central coordinator of immune responses, NF-κB signaling also plays a critical role in cancer development and progression and it may determine the response to therapy. NF-κB activation was shown to provide a critical mechanistic link between inflammation and cancer and is a major factor that controls the ability of both preneoplastic and malignant cells to resist apoptosis-based tumor surveillance mechanisms. NF-κB may also be involved in regulation of tumor angiogenesis and invasiveness. Importantly, NF-κB and the signaling pathways that mediate its activation have become attractive targets for development of new chemopreventive and chemotherapeutic approaches. © 2006 Wiley-Liss, Inc.

Get access to the full text of this article

Ancillary