Breast cancer prevention based on gene–environment interaction
Article first published online: 24 MAY 2010
Copyright © 2010 Wiley-Liss, Inc.
Special Issue: Exploring Cancer-related Genes: Application for Molecular Target-based Therapy and Prevention
Volume 50, Issue 4, pages 280–290, April 2011
How to Cite
Song, M., Lee, K.-M. and Kang, D. (2011), Breast cancer prevention based on gene–environment interaction. Mol. Carcinog., 50: 280–290. doi: 10.1002/mc.20639
- Issue published online: 25 MAR 2011
- Article first published online: 24 MAY 2010
- Manuscript Accepted: 22 MAR 2010
- Manuscript Revised: 17 MAR 2010
- Manuscript Received: 4 OCT 2009
- breast neoplasms;
Breast cancer, the most common cancer in women, results from combined effects of genetic and environmental factors. Although a number of preventive measures have been suggested to reduce the risk of breast cancer, only a few (e.g., regular mammogram, etc.) proved to be efficient preventive modalities. Among many potential reasons, differences in individual susceptibility factors may complicate the efficacy of the intervention. A growing body of evidence shows that the strength of association between various dietary, behavioral (exercise and obesity), and environmental exposures, and breast cancer risk may be modified by individual genetic factors. Preventive strategies against breast cancer will be discussed considering the findings of the gene–environment interaction of breast cancer. These include behavior modification for high-risk subjects (primary prevention), early detection and extensive monitoring of genetically susceptible subjects and noninvasive treatment of early stage cancer cases (secondary prevention), and finally prophylactic and therapeutic intervention to slow the progression of diseases (tertiary prevention). The accumulating evidences of the gene–environment interactions provide a better understanding of the breast cancer development and enable us to adopt individualized preventive strategies for personalized health care. © 2010 Wiley-Liss, Inc.