Research Article

Associations of lifestyle-related factors, hsa-miR-149 and hsa-miR-605 gene polymorphisms with gastrointestinal cancer risk

  1. Zhang MW1,
  2. Jin MJ1,
  3. Yu YX1,
  4. Zhang SC1,
  5. Liu B2,
  6. Jiang X1,
  7. Pan YF1,
  8. Li QL3,
  9. Ma XY3,
  10. Chen K1,*

Article first published online: 4 OCT 2011

DOI: 10.1002/mc.20863

Issue

Molecular Carcinogenesis

Molecular Carcinogenesis

Special Issue: Gene Polymorphisms and Susceptibility to Cancer

Volume 51, Issue S1, pages E21–E31, October 2012

Additional Information

How to Cite

MW, Z., MJ, J., YX, Y., SC, Z., B, L., X, J., YF, P., QL, L., XY, M. and K, C. (2012), Associations of lifestyle-related factors, hsa-miR-149 and hsa-miR-605 gene polymorphisms with gastrointestinal cancer risk. Mol. Carcinog., 51: E21–E31. doi: 10.1002/mc.20863

Author Information

  1. 1

    Department of Epidemiology and Health Statistics, College of Public Health, Zhejiang University, Hangzhou, Zhejiang, China

  2. 2

    Centers for Disease Control and Prevention of Hangzhou City, Hangzhou, Zhejiang, China

  3. 3

    Institute for Cancer Prevention of Jiashan County, Jiashan, Zhejiang, China

*Department of Epidemiology and Health Statistics, College of Public Health, Zhejiang University, Hangzhou, Zhejiang, China.

Publication History

  1. Issue published online: 4 OCT 2012
  2. Article first published online: 4 OCT 2011
  3. Manuscript Accepted: 9 SEP 2011
  4. Manuscript Revised: 2 SEP 2011
  5. Manuscript Received: 4 MAY 2011

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Keywords:

  • hsa-miR-605;
  • hsa-miR-149;
  • polymorphism;
  • gastrointestinal cancer;
  • susceptibility

Abstract

To explore the associations of SNPs within hsa-miR-605 (rs2043556) and hsa-miR-149 (rs2292832) and lifestyle-related factors with gastrointestinal cancer, a case–control study including 762 cases and 757 controls was conducted. Marginally significant associations were found both for hsa-miR-149 rs2292832 with gastric cancer risk (TC + CC vs. TT, OR = 0.68, 95% CI: 0.44–1.04) and for hsa-miR-605 rs2043556 with colorectal cancer risk (AG + GG vs. AA, OR = 0.70, 95% CI: 0.48–1.02) in males. Tea drinking showed a protective effect on gastric cancer risk (OR = 0.28, 95% CI: 0.13–0.60), while smoke inhalation increased the risk of gastric cancer (OR = 1.94, 95% CI: 1.08–3.47). Irritability was found to be a risk factor for both colorectal cancer (OR = 1.61, 95% CI: 1.02–2.53) and gastric cancer (OR = 1.96, 95% CI: 1.17–3.29). Among those that engaged in smoke inhalation, miR-149 CT/CC and miR-605 AG/GG genotype carriers had increased susceptibilities to colorectal cancer (OR = 1.90, 95% CI: 1.11–3.25) and gastric cancer (OR = 1.87, 95% CI: 1.03–3.42), respectively. Among the tea drinkers, there exists a marginally protective effect of miR-605 AG/GG genotypes on colorectal cancer incidence (OR = 0.71, 95% CI: 0.47–1.06) and a significantly protective effect of miR-149 CT/CC on gastric cancer incidence (OR = 0.47, 95% CI: 0.29–0.77). The SNPs of rs2292832 and rs2043556 might be able to modify the susceptibility to male gastric and colorectal cancers, respectively. Tea drinking is a protective factor, while smoke inhalation is a risk factor for gastric cancer, and they might have the potential to modify the associations between miR-149 and miR-605 polymorphisms with gastrointestinal cancer risk. In addition, irritability was shown to be a risk factor for both gastric and colorectal cancers. © 2011 Wiley Periodicals, Inc.

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