Policy debates suggest a future role for geologic carbon sequestration. As geologic sequestration (GS) evolves from enhanced oil recovery operations to an emissions-mitigation option, regulations must evolve to manage the risks of carbon dioxide (CO2) migration. We develop an engineering-economic model to understand the key deployment pathways in this transition. Major results reveal that dedicated CO2 storage in aquifers is associated with the greatest net revenues under only a limited number of scenarios. This finding suggests that regulators should anticipate GS operations in reservoirs that were not initially intended as GS operations and, therefore, may have higher leakage rates. Copyright © 2013 John Wiley & Sons, Ltd.