Do risk factors for Alzheimer's disease predict dementia in Parkinson's disease? An exploratory study

Authors

  • Gilberto Levy MD,

    1. Gertrude H. Sergievsky Center, College of Physicians and Surgeons, Columbia University, New York, New York, USA
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  • Ming-Xin Tang PhD,

    1. Gertrude H. Sergievsky Center, College of Physicians and Surgeons, Columbia University, New York, New York, USA
    2. Division of Biostatistics, School of Public Health, Columbia University, New York, New York, USA
    3. The Taub Institute for Research on Alzheimer's Disease and The Aging Brain, Columbia University, New York, New York, USA
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  • Lucien J. Cote MD,

    1. Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, New York, USA
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  • Elan D. Louis MD, MS,

    1. Gertrude H. Sergievsky Center, College of Physicians and Surgeons, Columbia University, New York, New York, USA
    2. Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, New York, USA
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  • Brenda Alfaro MA,

    1. Gertrude H. Sergievsky Center, College of Physicians and Surgeons, Columbia University, New York, New York, USA
    2. Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, New York, USA
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  • Helen Mejia MA,

    1. Gertrude H. Sergievsky Center, College of Physicians and Surgeons, Columbia University, New York, New York, USA
    2. Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, New York, USA
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  • Yaakov Stern PhD,

    1. Gertrude H. Sergievsky Center, College of Physicians and Surgeons, Columbia University, New York, New York, USA
    2. Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, New York, USA
    3. Department of Psychiatry, College of Physicians and Surgeons, Columbia University, New York, New York, USA
    4. The Taub Institute for Research on Alzheimer's Disease and The Aging Brain, Columbia University, New York, New York, USA
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  • Karen Marder MD, MPH

    Corresponding author
    1. Gertrude H. Sergievsky Center, College of Physicians and Surgeons, Columbia University, New York, New York, USA
    2. Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, New York, USA
    3. The Taub Institute for Research on Alzheimer's Disease and The Aging Brain, Columbia University, New York, New York, USA
    • G.H. Sergievsky Center, 630 West 168th Street, New York, New York, 10032
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Abstract

The extent to which concomitant Alzheimer's disease (AD) is etiologically related to the development of dementia in Parkinson's disease (PD) remains controversial. We explored the association of four risk factors associated with AD, including head injury, smoking, hypertension, and diabetes mellitus, with incident dementia in PD. A cohort of 180 nondemented PD patients from the Washington Heights community in northern Manhattan, New York, completed a risk factor questionnaire at baseline and was followed annually with neurological and neuropsychological evaluations. The association of baseline variables with incident dementia was analyzed by using Cox proportional hazards models. All analyses controlled for age at baseline, gender, years of education, duration of PD, and total Unified Parkinson's Disease Rating Scale (UPDRS) motor score at baseline. Of 180 patients (mean age, 71.0 ± 10.3 years), 52 (29%) became demented during a mean follow-up period of 3.6 ± 2.2 years. Head injury risk ratio ([RR] 0.9; 95% confidence interval [CI], 0.4–2.2; P = 0.9), hypertension (RR, 0.7; 95% CI, 0.4–1.4, P = 0.3), and diabetes mellitus (RR, 0.8; 95% CI, 0.3–2.3; P = 0.7) were not significantly associated with incident dementia in the Cox models. Patients who reported having ever smoked were at increased risk for the development of dementia compared with nonsmokers (RR, 2.0; 95% CI, 1.0–3.9; P = 0.05). Current smoking was significantly associated with incident dementia (RR, 4.5; 95% CI, 1.2–16.4; P = 0.02), whereas past smoking approached significance (RR, 1.9; 95% CI, 0.9–3.7; P = 0.07). Although an inverse association between smoking and PD has been reported in several studies, our study showed a positive association between smoking and dementia in the setting of PD. The association of smoking with incident dementia in PD deserves further study. © 2002 Movement Disorder Society.

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