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Keywords:

  • parkin;
  • dopamine;
  • Parkinson's disease;
  • PET;
  • genetics

Abstract

There are few reports of positron emission tomography (PET) in juvenile parkinsonism (JP). We report on the results of 18F-6-fluoro-L-dopa (FD) PET in a 14-year-old patient with JP of 5 years duration associated with atypical features. This is the youngest subject to be investigated to date. There was a severe asymmetric reduction in striatal FD uptake, with a rostrocaudal gradient in the putamen similar to that seen in adult-onset idiopathic parkinsonism. Extensive DNA analysis in this patient did not show mutations in the parkin gene. © 2002 Movement Disorder Society