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Keywords:

  • Parkinson's disease;
  • dopamine transporter;
  • polymorphism;
  • case-control study;
  • early-onset Parkinson's disease

Abstract

We studied a polymorphism in the dopamine transporter (DAT) gene in 236 Japanese patients with Parkinson's disease (PD) and compared the results with 220 controls. The 1215A/G genotype of the DAT gene was significantly different between PD patients and controls, suggesting a possible involvement of DAT in genetic susceptibility to PD. © 2002 Movement Disorder Society