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Globus pallidus internus deep brain stimulation for dystonic conditions: A prospective audit

Authors

  • John Yianni MRCS,

    1. The Oxford Movement Disorder Group, Department of Neurological Surgery, The Radcliffe Infirmary, Oxford, United Kingdom
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  • Peter Bain MA, MD, FRCP,

    1. Division of Neurosciences and Psychological Medicine, Imperial College School of Medicine, Charing Cross Hospital Campus, London, United Kingdom
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  • Nir Giladi MD,

    1. Movement Disorders Unit, Department of Neurology, Tel-Aviv Sourasky Medical Centre, Sackler School of Medicine, Tel-Aviv University, Tel-Aviv, Israel
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  • Marieta Auca MD,

    1. Movement Disorders Unit, Department of Neurology, Tel-Aviv Sourasky Medical Centre, Sackler School of Medicine, Tel-Aviv University, Tel-Aviv, Israel
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  • Ralph Gregory FRCP,

    1. The Oxford Movement Disorder Group, Department of Neurological Surgery, The Radcliffe Infirmary, Oxford, United Kingdom
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  • Carole Joint RGN,

    1. The Oxford Movement Disorder Group, Department of Neurological Surgery, The Radcliffe Infirmary, Oxford, United Kingdom
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  • Dipankar Nandi MCH,

    1. University Department of Physiology, Oxford University, Oxford, United Kingdom
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  • John Stein BM, BCH, DPhil,

    1. University Department of Physiology, Oxford University, Oxford, United Kingdom
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  • Richard Scott PhD, M.Appl.Sci,

    1. The Oxford Movement Disorder Group, Department of Neurological Surgery, The Radcliffe Infirmary, Oxford, United Kingdom
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  • Tipu Aziz MD, FRCS

    Corresponding author
    1. The Oxford Movement Disorder Group, Department of Neurological Surgery, The Radcliffe Infirmary, Oxford, United Kingdom
    2. Division of Neurosciences and Psychological Medicine, Imperial College School of Medicine, Charing Cross Hospital Campus, London, United Kingdom
    3. University Department of Physiology, Oxford University, Oxford, United Kingdom
    • Department of Neurological Surgery, The Radcliffe Infirmary, Oxford OX2 6HE, United Kingdom
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Abstract

In the current era of functional surgery for movement disorders, deep brain stimulation (DBS) of the globus pallidus internus (GPi) is emerging as the favoured target in the treatment of patients with dystonia. The results of 25 consecutive patients with medically intractable dystonia (12 with generalised dystonia, 7 with spasmodic torticollis, and 6 with other types of dystonia) treated with GPi stimulation are reported. Although comparisons were limited by differences in their respective neurological rating scales, chronic DBS benefited all groups, resulting in clear and progressive improvements in their condition. This study clearly demonstrates that DBS of the GPi provides amelioration of intractable dystonia. © 2002 Movement Disorder Society

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