Nocturnal body core temperature falls in Parkinson's disease but not in multiple-system atrophy
Article first published online: 7 MAR 2001
Copyright © 2001 Movement Disorder Society
Volume 16, Issue 2, pages 226–232, March 2001
How to Cite
Pierangeli, G., Provini, F., Maltoni, P., Barletta, G., Contin, M., Lugaresi, E., Montagna, P. and Cortelli, P. (2001), Nocturnal body core temperature falls in Parkinson's disease but not in multiple-system atrophy. Mov. Disord., 16: 226–232. doi: 10.1002/mds.1039
- Issue published online: 28 MAR 2001
- Article first published online: 7 MAR 2001
- Manuscript Accepted: 10 JUL 2000
- Manuscript Revised: 5 JUL 2000
- Manuscript Received: 20 APR 2000
- MURST. Grant Numbers: ex 60% 1994, COFIN 99, prot. 9906037938_007
- multiple system atrophy;
- Parkinson's disease;
- circadian rhythm;
- body temperature;
- autonomic failure
To evaluate whether the circadian rhythm of body core temperature (CRT°) can differentiate Multiple-System Atrophy (MSA) from Idiopathic Parkinson's disease (IPD).
We evaluated 14 patients with probable MSA, seven with IPD, and eight controls. After a preliminary evaluation of cardiovascular autonomic function, rectal temperature and sleep-wake cycle were monitored continuously for 48 hours in a temperature-controlled room, at constant bed rest with controlled food intake and fixed light-dark schedule.
MSA patients showed cardiovascular autonomic sympathetic and parasympathetic failure. IPD had normal cardiovascular autonomic function. A 24-hour rhythm of body core temperature (BcT°) was present in all subjects. IPD had CRT° comparable to controls. In MSA the mesor was higher and mean BcT° of each hour was significantly higher from 11 p.m. to 7 a.m. The analysis of mean BcT° during the different sleep phases showed significantly higher values during both NREM (1–2, 3–4) and REM sleep stages in MSA.
The physiological nocturnal fall of BcT° is blunted in MSA patients mainly because BcT° did not decrease during sleep. This CRT° pattern is not justified by differences in sleep structure and may reflect an impairment of central sympathetic nervous system function. © 2001 Movement Disorder Society.