Essential tremor is not associated with α-synuclein gene haplotypes



A specific allele of the NACP-Rep1 polymorphism within the α-synuclein promoter was found to be associated both with Parkinson's disease and essential tremor. We repeated the association study on a large series of Italian patients with essential tremor using a panel of polymorphisms within the α-synuclein gene. Our results did not confirm the association reported previously and failed to identify a α-synuclein specific haplotype as susceptibility factor for essential tremor. © 2003 Movement Disorder Society