Prevalence of Parkinson's disease and related disorders in the elderly population of greater Beijing, China

Authors

  • Zhen-Xin Zhang MD,

    1. Department of Neurology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, China
    2. Department of Clinical Epidemiology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, China
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  • Dallas W. Anderson PhD,

    Corresponding author
    1. Population Studies Unit, Biostatistics Branch, National Institute of Neurological Disorders and Stroke, Bethesda, Maryland, USA
    • National Institutes of Health, National Institute of Neurological Disorders and Stroke, Neuroscience Center, Room 2156, 6001 Executive Blvd (MSC 9531), Bethesda, MD 20892-9531
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  • Jue-Bin Huang MD,

    1. Department of Neurology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, China
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  • Hui Li MD, MPH,

    1. Department of Epidemiology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, China
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  • Xia Hong MD,

    1. Department of Neurology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, China
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  • Jing Wei MD,

    1. Department of Neurology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, China
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  • En-Li Yang MD,

    1. Department of Neurology, The Sixth Hospital of Beijing, Beijing, China
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  • Demetrius M. Maraganore MD

    1. Department of Neurology, Mayo Clinic and Mayo Foundation, Rochester, Minnesota, USA
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Abstract

A lower prevalence of Parkinson's disease (PD) has been reported for Chinese populations, but it is unclear whether this observation reflects a lower disease risk or is an artifact of case finding. We ascertained the prevalence of PD in elderly residents of an area that was a composite of 27 urban and rural communities of Greater Beijing, China. A team of university neurologists went door-to-door throughout the study area, examining 5,743 residents (at age 55 years or older) and made preliminary determinations of which residents had PD or other types of parkinsonism. Final determinations were made after follow-up and reevaluation of those persons who were either deemed to have parkinsonism or were suspected of having the condition (n = 144; median follow-up = 40 months). Based on stringent diagnostic criteria, 110 persons were identified to have parkinsonism, of whom 64 (58%) had PD. The prevalence of PD increased with advancing age and was about 1% overall and for each gender. In rural communities, 22 persons had PD, but 20 persons (91%) were first diagnosed for this condition by the study neurologists. The prevalence figures obtained in this study are similar to some of the highest prevalence figures reported in the West. © 2003 Movement Disorder Society

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