Get access

Phenotypic features of Huntington's disease-like 2

Authors

  • Ruth H. Walker MB, ChB, PhD,

    Corresponding author
    1. Department of Neurology, Veterans Affairs Medical Center, Bronx Mount Sinai School of Medicine, New York, New York, USA
    • Department of Neurology, Box 1137, Mount Sinai School of Medicine, One Gustave L. Levy Place, NY, NY 10029
    Search for more papers by this author
  • Joseph Jankovic MD,

    1. Baylor College of Medicine, Department of Neurology, Parkinson's Disease Center and Movement Disorders Clinic, Houston, Texas, USA
    Search for more papers by this author
  • Elizabeth O'Hearn MD,

    1. Department of Neurology and Neuroscience, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Search for more papers by this author
  • Russell L. Margolis MD

    1. Department of Psychiatry and Program in Cellular and Molecular Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Search for more papers by this author

  • A videotape accompanies this article.

Abstract

Huntington's disease-like 2 is an autosomal dominantly inherited disorder due to an expansion of trinucleotide repeats. It resembles classic Huntington's disease in clinical phenotype, inheritance pattern, and neuropathological features. We highlight the clinical features of this disorder, including chorea, dystonia, parkinsonism, and cognitive deficits. © 2003 Movement Disorder Society

Get access to the full text of this article

Ancillary