Hyperhomocysteinaemia in treated patients with Huntington's disease homocysteine in HD

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Abstract

Significantly increased plasma total homocysteine levels (t-Hcys) appeared in treated Huntington disease (HD) patients compared to controls and untreated HD subjects. Because the protein Huntingtin interacts with the homocysteine metabolism modulating enzyme cystathionine β-synthase, we hypothesize that homocysteine promotes neurodegeneration in HD. © 2003 Movement Disorder Society

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