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Senile chorea treated by deep brain stimulation—A clinical, neurophysiological and functional imaging study

Authors

  • John Yianni MRCS,

    1. The Oxford Movement Disorder Group, Department of Neurological Surgery, The Radcliffe Infirmary, Oxford, United Kingdom
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  • Dipankar Nandi MCh,

    1. The Oxford Movement Disorder Group, Department of Neurological Surgery, The Radcliffe Infirmary, Oxford, United Kingdom
    2. University Laboratory of Physiology, Oxford University, Oxford, United Kingdom
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  • Kevin Bradley MA, MRCP, FRCR,

    1. Oxford Project to Investigate Memory and Aging (OPTIMA), The Radcliffe Infirmary, Oxford, United Kingdom
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  • Nigel Soper MSc,

    1. Oxford Project to Investigate Memory and Aging (OPTIMA), The Radcliffe Infirmary, Oxford, United Kingdom
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  • Ralph Gregory FRCP,

    1. The Oxford Movement Disorder Group, Department of Neurological Surgery, The Radcliffe Infirmary, Oxford, United Kingdom
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  • Carole Joint RGN,

    1. The Oxford Movement Disorder Group, Department of Neurological Surgery, The Radcliffe Infirmary, Oxford, United Kingdom
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  • John Stein BM, BCh, FRCP,

    1. University Laboratory of Physiology, Oxford University, Oxford, United Kingdom
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  • Richard Scott PhD, MApplSci,

    1. The Oxford Movement Disorder Group, Department of Neurological Surgery, The Radcliffe Infirmary, Oxford, United Kingdom
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  • Tipu Aziz MD, FRCS

    Corresponding author
    1. The Oxford Movement Disorder Group, Department of Neurological Surgery, The Radcliffe Infirmary, Oxford, United Kingdom
    2. University Laboratory of Physiology, Oxford University, Oxford, United Kingdom
    • Department of Neurological Surgery, The Radcliffe Infirmary, Oxford OX2 6HE, UK
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  • A videotape accompanies this article.

Abstract

We report on a patient with senile chorea, treated with deep brain stimulation of the left globus pallidus internus and subsequently the left ventralis oralis posterior nucleus of the thalamus. Deep brain field potential recordings and functional imaging using single photon emission tomography enabled us to suggest pathophysiological mechanisms for the symptoms. © 2004 Movement Disorder Society

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