Dr. Benedetti conducted this study while on leave from the Department of Neurology, University of Verona, Italy.
Hysterectomy, menopause, and estrogen use preceding Parkinson's disease: An exploratory case-control study†
Article first published online: 6 SEP 2001
Copyright © 2001 Movement Disorder Society
Volume 16, Issue 5, pages 830–837, September 2001
How to Cite
Benedetti, M. D., Maraganore, D. M., Bower, J. H., McDonnell, S. K., Peterson, B. J., Ahlskog, J. E., Schaid, D. J. and Rocca, W. A. (2001), Hysterectomy, menopause, and estrogen use preceding Parkinson's disease: An exploratory case-control study. Mov. Disord., 16: 830–837. doi: 10.1002/mds.1170
Presented in part at the 5th International Congress of Parkinson's Disease and Movement Disorders; New York, NY, October 1998.
- Issue published online: 12 OCT 2001
- Article first published online: 6 SEP 2001
- Manuscript Accepted: 8 DEC 2000
- Manuscript Revised: 22 NOV 2000
- Manuscript Received: 26 MAY 2000
- Parkinson's disease;
- case-control study;
We studied the association of Parkinson's disease (PD) with type of menopause (natural or surgical), age at menopause, and postmenopausal estrogen replacement therapy using a case-control design. We used the medical records-linkage system of the Rochester Epidemiology Project to identify 72 women who developed PD in Olmsted County, MN, during the twenty years 1976–1995. Each incident case was matched by age (± 1 year) to a general population control subject. We collected exposure data through review of the complete medical records of cases and control subjects in the system. PD cases had undergone hysterectomy (with or without unilateral oophorectomy) significantly more often than control subjects (odds ratio [OR] = 3.36; 95% confidence interval [CI] = 1.05–10.77). In addition, PD cases had experienced early menopause (≤ 46 years) more commonly than control subjects (OR = 2.18; 95% CI = 0.88–5.39). Finally, PD cases had used estrogens orally or parenterally for at least 6 months after menopause less frequently (8%) than control subjects (14%; OR = 0.47; 95% CI = 0.12–1.85). However, the findings for early menopause and estrogen replacement therapy were not statistically significant. Despite the limited sample size of this exploratory study, we hypothesize that there is an increased risk of PD in conditions causing an early reduction in endogenous estrogen. This hypothesis needs to be confirmed in a larger study. © 2001 Movement Disorder Society.