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Unilateral periodic limb movements during sleep in corticobasal degeneration†
Article first published online: 30 OCT 2001
Copyright © 2001 Movement Disorder Society
Volume 16, Issue 6, pages 1180–1183, November 2001
How to Cite
Iriarte, J., Alegre, M., Arbizu, J. and de Castro, P. (2001), Unilateral periodic limb movements during sleep in corticobasal degeneration. Mov. Disord., 16: 1180–1183. doi: 10.1002/mds.1227
- Issue published online: 29 NOV 2001
- Article first published online: 30 OCT 2001
- Manuscript Accepted: 19 SEP 2000
- Manuscript Revised: 17 AUG 2000
- Manuscript Received: 12 JUL 1999
Periodic limb movements in sleep (PLM) have been associated with several degenerative disorders and other focal or diffuse diseases. We present a patient with clinical diagnosis of corticobasal degeneration and sleep complaints, in whom video recording and polygraphic study confirmed the presence of right PLM. The unilaterality of the movements and the positron emission tomography findings (hypometabolism in the left frontoparietal, basal ganglia, and thalamic areas) suggest that the loss of inhibitory descending central pathways, with origin in the cortex or basal ganglia, may be involved in the pathogenesis of PLM. © 2001 Movement Disorder Society.