A consanguineous Turkish family with early-onset Parkinson's disease and an exon 4 parkin deletion

Authors

  • Okan Dogu MD,

    Corresponding author
    1. Movement Disorders Unit, Department of Neurology, Faculty of Medicine, Mersin University, Mersin, Turkey
    2. Laboratory of Neurogenetics, National Institute on Aging and National Institute on Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, USA
    • Movement Disorders Unit, Department of Neurology Faculty of Medicine, Mersin University, Mersin Universitesi Hastanesi, Noroloji AD. Zeytinlibahce cad. 33070 Mersin, Turkey
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  • Janel Johnson BS,

    1. Laboratory of Neurogenetics, National Institute on Aging and National Institute on Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, USA
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  • Dena Hernandez MS,

    1. Laboratory of Neurogenetics, National Institute on Aging and National Institute on Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, USA
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  • Melissa Hanson MS,

    1. Laboratory of Neurogenetics, National Institute on Aging and National Institute on Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, USA
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  • John Hardy PhD,

    1. Laboratory of Neurogenetics, National Institute on Aging and National Institute on Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, USA
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  • Hulya Apaydin MD,

    1. Department of Neurology, Cerrahpasa Medical School, Istanbul University, Istanbul, Turkey
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  • Sibel Özekmekçi MD,

    1. Department of Neurology, Cerrahpasa Medical School, Istanbul University, Istanbul, Turkey
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  • Serhan Sevim MD,

    1. Movement Disorders Unit, Department of Neurology, Faculty of Medicine, Mersin University, Mersin, Turkey
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  • Katrina Gwinn-Hardy MD,

    1. Laboratory of Neurogenetics, National Institute on Aging and National Institute on Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, USA
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  • Andrew Singleton PhD

    1. Laboratory of Neurogenetics, National Institute on Aging and National Institute on Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, USA
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Abstract

The importance of parkin in early-onset Parkinson's disease in Japan, Europe, and the United States is well established. The contribution of this gene to the risk of Parkinson's disease in other populations is less well known. To explore the importance of parkin in those of Turkish ancestry, we studied familial cases from that country, and identified a consanguineous family with early-onset Parkinson's disease due to a homozygous mutation in parkin. © 2004 Movement Disorder Society

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