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Visual hallucination in Parkinson's disease with FDG PET

Authors

  • Atsuko Nagano-Saito MD, PhD,

    1. Department of Brain Science and Molecular Imaging, National Institute for Longevity Sciences, National Center for Geriatrics and Gerontology, Obu, Japan
    2. Department of Neurology, Chubu National Hospital, Obu, Japan
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  • Yukihiko Washimi MD, PhD,

    1. Department of Neurology, Chubu National Hospital, Obu, Japan
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  • Yutaka Arahata MD, PhD,

    1. Department of Brain Science and Molecular Imaging, National Institute for Longevity Sciences, National Center for Geriatrics and Gerontology, Obu, Japan
    2. Department of Neurology, Chubu National Hospital, Obu, Japan
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  • Katsushige Iwai MD,

    1. Department of Neurology, Chubu National Hospital, Obu, Japan
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  • Shoji Kawatsu MD, PhD,

    1. Department of Brain Science and Molecular Imaging, National Institute for Longevity Sciences, National Center for Geriatrics and Gerontology, Obu, Japan
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  • Kengo Ito MD, PhD,

    Corresponding author
    1. Department of Brain Science and Molecular Imaging, National Institute for Longevity Sciences, National Center for Geriatrics and Gerontology, Obu, Japan
    • Department of Brain Science and Molecular Imaging, National Institute for Longevity Sciences, National Center for Geriatrics and Gerontology, 36-3 Gengo Morioka-Cho, Obu, Aichi 474-8522, Japan
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  • Akinori Nakamura MD, PhD,

    1. Department of Brain Science and Molecular Imaging, National Institute for Longevity Sciences, National Center for Geriatrics and Gerontology, Obu, Japan
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  • Yuji Abe MD, PhD,

    1. Department of Neurology, Chubu National Hospital, Obu, Japan
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  • Takako Yamada MD, PhD,

    1. Department of Neurology, Chubu National Hospital, Obu, Japan
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  • Takashi Kato MD, PhD,

    1. Department of Brain Science and Molecular Imaging, National Institute for Longevity Sciences, National Center for Geriatrics and Gerontology, Obu, Japan
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  • Teruhiko Kachi MD, PhD

    1. Department of Neurology, Chubu National Hospital, Obu, Japan
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Abstract

To determine the characteristics of cerebral glucose metabolism in Parkinson's disease patients with visual hallucinations, group comparison studies using [18F]fluorodeoxyglucose positron emission tomography were performed. Nondemented Parkinson's disease patients in advanced stages were classified into two groups: (1) patients without visual hallucinations; (2) patients with visual hallucinations. Compared to patients without hallucinations, the relative regional cerebral glucose metabolic rate was greater in the frontal areas in patients with visual hallucinations, and the increase reached a significant level in the left superior frontal gyrus. Relative frontal hypermetabolism may be a feature of Parkinson's disease patients with visual hallucinations. © 2004 Movement Disorder Society

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