Reversible parkinsonism following heroin pyrolysate inhalation is associated with tetrahydrobiopterin deficiency

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Abstract

A patient who inhaled heroin vapour (chasing the dragon), resulting in temporary parkinsonism, is described. A reversible deficiency of tetrahydrobiopterin, causing altered dopamine metabolism, is demonstrated as the metabolic basis of this aspect of the encephalopathy. © 2004 Movement Disorder Society

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