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Keywords:

  • amantadine;
  • levodopa-induced dyskinesias;
  • GTP cyclohydrolase I deficiency

Abstract

Amantadine suppressed severe levodopa-induced choreic dyskinesia, which developed at initiation of levodopa therapy, in two siblings manifesting dystonia with motor delay phenotype of GTP cyclohydrolase I deficiency caused by compound heterozygous GCH1 mutations. Our finding suggests a beneficial effect of amantadine on this type of dyskinesia frequently observed in relatively severe dopamine-deficient metabolic disorders. © 2004 Movement Disorder Society