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Keywords:

  • tremor;
  • Parkinson's disease;
  • UPDRS;
  • akinesia;
  • deep brain stimulation;
  • synchronization;
  • oscillations

Abstract

Recently, a pathological oscillatory network at 10 Hz including several motor areas was described in patients with idiopathic Parkinson's disease (PD). In 7 PD patients, we tested the clinical effect of subthalamic nucleus (STN) stimulation at varying frequencies 1 to 3 years after implantation of electrodes. STN stimulation at 10 Hz induced significant worsening of motor symptoms, especially akinesia, compared with no stimulation and therapeutic stimulation (≥130 Hz). This finding indicates the clinical relevance of pathological 10 Hz synchronization in PD. © 2004 Movement Disorder Society