Continuous subcutaneous apomorphine therapy improves dyskinesias in Parkinson's disease: A prospective study using single-dose challenges

Authors

  • Regina Katzenschlager MD,

    1. Reta Lila Weston Institute of Neurological Studies, University College London, United Kingdom
    2. The National Hospital for Neurology and Neurosurgery, Queen Square, London, United Kingdom
    3. Department of Neurology, Donauspital/Sozialmedizinisches Zentrum-Ost, Vienna, Austria
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  • Andrew Hughes MD, FRACP,

    1. Austin and Repatriation Medical Centre, West Heidelberg, Victoria, Australia
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  • Andrew Evans MBBS, FRACP,

    1. Reta Lila Weston Institute of Neurological Studies, University College London, United Kingdom
    2. The National Hospital for Neurology and Neurosurgery, Queen Square, London, United Kingdom
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  • Alice J. Manson MRCP,

    1. Wessex Neurological Centre, Southampton, United Kingdom
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  • Marion Hoffman RNBA,

    1. Austin and Repatriation Medical Centre, West Heidelberg, Victoria, Australia
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  • Lesley Swinn RGN, MSc,

    1. The National Hospital for Neurology and Neurosurgery, Queen Square, London, United Kingdom
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  • Hilary Watt MSc,

    1. Medical Statistics Unit, London School of Hygiene and Tropical Medicine and Institute of Neurology, Queen Square, London, United Kingdom
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  • Kailash Bhatia MD, FRCP,

    1. Sobell Department of Motor Neurosciences and Movement Disorders, Institute of Neurology, University College London, United Kingdom
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  • Niall Quinn MD, FRCP,

    1. Sobell Department of Motor Neurosciences and Movement Disorders, Institute of Neurology, University College London, United Kingdom
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  • Andrew J. Lees MD, FRCP

    Corresponding author
    1. Reta Lila Weston Institute of Neurological Studies, University College London, United Kingdom
    2. The National Hospital for Neurology and Neurosurgery, Queen Square, London, United Kingdom
    • Reta Lila Weston Institute of Neurological Studies, Windeyer Building, 46 Cleveland Street, London W1 T 4JF United Kingdom
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Abstract

Continuous subcutaneous (SC) infusion of the dopamine agonist apomorphine was shown in retrospective studies to improve drug-induced dyskinesias in Parkinson's disease (PD). We prospectively assessed the antidyskinetic effect of continuous SC apomorphine therapy using subjective and objective measures, and sought to determine whether any observed dyskinesia reduction could be corroborated using single-dose dopaminergic challenges. Twelve PD patients with onoff fluctuations and disabling dyskinesias who were scheduled to start apomorphine pump treatment underwent acute levodopa and apomorphine challenges at baseline and 6 months later. Video recordings involving motor tasks were rated blindly by two independent raters using modified AIMS and Goetz dyskinesia scales. At 6 months, mean apomorphine dose was 75.2 mg per day and the mean l-dopa dose had been reduced by 55%. Daily off time in patients' diaries was reduced by 38% (2.4 hours). The l-dopa challenges showed a reduction of 44% in AIMS and 40% in Goetz scores (both P < 0.01). Apomorphine challenges showed a reduction of 39% in AIMS and 36% in Goetz scores (both P < 0.01). Patients' self-assessment scores reflected these significant changes. Dyskinesia improvement correlated with reduction in oral medication and with the final apomorphine dose (P < 0.05). This prospective study confirms marked dyskinesia reduction on continuous subcutaneous apomorphine therapy, paralleled by reduced dyskinesias during dopaminergic challenge tests. Our findings support the concept that replacement of short-acting oral antiparkinsonian medication with continuous dopamine receptor stimulation may reverse, at least partially, the sensitization process believed to mediate the development of drug-induced dyskinesias in PD. © 2004 Movement Disorder Society

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