Clinical grand round: A rapidly progressive pyramidal and extrapyramidal syndrome with a supranuclear gaze palsy

Authors

  • H.R. Morris PhD, MRCP,

    1. Reta Lila Weston Institute of Neurological Studies, Royal Free And University College London Medical School, Windeyer Building, London, United Kingdom
    2. Department of Neurology, School of Medicine, Cardiff University, Heath Park, Cardiff, United Kingdom
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  • Adolfo M. Bronstein MD,

    1. Academic Department of Neuro-otology, Division of Neuroscience and Psychological Medicine, Imperial College Faculty of Medicine, Charing Cross Hospital, London, United Kingdom
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  • Christopher E. Shaw MB, BCh, MD, FRACP, FRCP,

    1. Departments of Neurology and Medical and Molecular Genetics, Guy's, King's and St. Thomas' School of Medicine and the Institute of Psychiatry, London, United Kingdom
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  • Andrew J. Lees MD, FRCP,

    Corresponding author
    1. Reta Lila Weston Institute of Neurological Studies, Royal Free And University College London Medical School, Windeyer Building, London, United Kingdom
    • Reta Lila Weston Institute of Neurological Studies, Royal Free And University College London Medical School, Windeyer Building, 46 Cleveland Street, London W1T 4JF, United Kingdom
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  • S. Love MB, BCh, PhD

    1. Department of Neuropathology, Frenchay Hospital, Bristol, United Kingdom
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Abstract

The case history of a patient with a rapidly progressive spastic tetraparesis, pseudobulbar palsy, supranuclear gaze palsy, and extrapyramidal signs is presented. The patient died 17 months after symptom onset, and the differential diagnosis and pathological findings are reviewed. © 2005 Movement Disorder Society

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