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Hemiparkinsonism and levodopa-induced dyskinesias after focal nigral lesion

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Abstract

We present a patient with tremor-dominant hemiparkinsonism after a focal lesion to the substantia nigra. An excellent response to levodopa was complicated by rapid development of motor fluctuations and disabling dyskinesias. Stereotactic thalamotomy resulted in a persistent extinction of parkinsonism and of dyskinesias along with stopping dopaminergic treatment. © 2005 Movement Disorder Society

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