Association between male gender and pediatric essential tremor

Authors

  • Elan D. Louis MD, MS,

    Corresponding author
    1. Gertrude H. Sergievsky Center, College of Physicians and Surgeons, Columbia University, New York, New York, USA
    2. Taub Institute for Research or Alzheimer's Disease and the Aging Brain, College of Physicians and Surgeons, Columbia University, New York, New York, USA
    • Unit 198, Neurological Institute, 710 West 168th Street, New York, NY
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  • Emilio Fernandez-Alvarez MD,

    1. Department of Child Neurology, Hospital San Juan de Dios, Barcelona, Spain
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  • Leon S. Dure IV MD,

    1. University of Alabama at Birmingham, Birmingham, Alabama, USA
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  • Steven Frucht MD,

    1. Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, New York, USA
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  • Blair Ford MD

    1. Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, New York, USA
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Abstract

Approximately 5% of new essential tremor (ET) cases arise during childhood. The goal of the current report was to examine the possible association between male gender and pediatric ET, using data from 95 pediatric ET cases seen at three medical centers (two in the United States and one in Spain). The odds of ET in our sample of cases were threefold higher in boys compared to girls. Whether this association between male gender and pediatric ET represents a selection bias or a true gender-mediated biological difference in disease expression is not known, although some data support the latter possibility. © 2005 Movement Disorder Society

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