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Can chronic subthalamic nucleus stimulation induce de novo tremor in Parkinson's disease?

Authors

  • Stephane Thobois MD, PhD,

    Corresponding author
    1. Sobell Department of Motor Neurosciences and Movement Disorders, Unit of Functional Neurosurgery, Institute of Neurology, London, United Kingdom
    2. Service de Neurologie D, Hopital Neurologique et Neurochirurgical Pierre Wertheimer, Lyon, France
    • Sobell Department of Motor Neurosciences and Movement Disorders, Institute of Neurology, Box 146, 8/11 Queen Square, London WC1N 3BG, United Kingdom
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  • Stephen Tisch MBBS,

    1. Sobell Department of Motor Neurosciences and Movement Disorders, Unit of Functional Neurosurgery, Institute of Neurology, London, United Kingdom
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  • Jing Xie-Brustolin MD, PhD,

    1. Service de Neurologie D, Hopital Neurologique et Neurochirurgical Pierre Wertheimer, Lyon, France
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  • Patrick Mertens MD, PhD,

    1. Service de Neurochirurgie A, Hopital Neurologique et Neurochirurgical Pierre Wertheimer, Lyon, France
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  • Marwan I. Hariz MD, PhD,

    1. Sobell Department of Motor Neurosciences and Movement Disorders, Unit of Functional Neurosurgery, Institute of Neurology, London, United Kingdom
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  • Isabelle Benatru MD,

    1. Service de Neurologie D, Hopital Neurologique et Neurochirurgical Pierre Wertheimer, Lyon, France
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  • Emmanuel Broussolle MD, PhD,

    1. Service de Neurologie D, Hopital Neurologique et Neurochirurgical Pierre Wertheimer, Lyon, France
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  • Patricia Limousin-Dowsey MD, PhD

    1. Sobell Department of Motor Neurosciences and Movement Disorders, Unit of Functional Neurosurgery, Institute of Neurology, London, United Kingdom
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Abstract

Subthalamic nucleus stimulation dramatically improves parkinsonian symptoms, notably the tremor. The occurrence of a tremor in the first 6 months after the surgical procedure in patients without tremor preoperatively is much less common. We report on the cases of 3 patients who developed such modification of their parkinsonian symptomatology. Physiopathological hypotheses are discussed. © 2005 Movement Disorder Society

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