Paraneoplastic chorea with leukoencephalopathy presenting with obsessive–compulsive and behavioral disorder

Authors

  • Susanne Muehlschlegel MD,

    Corresponding author
    1. Department of Neurology, Movement Disorders Center, University of Florida College of Medicine, Gainesville, Florida, USA
    • PO Box 100236, Gainesville, FL 32605
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  • Michael S. Okun MD,

    1. Department of Neurology, Movement Disorders Center, University of Florida College of Medicine, Gainesville, Florida, USA
    2. Department of Neurological Surgery, University of Florida College of Medicine, Gainesville, Florida, USA
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  • Kelly D. Foote MD,

    1. Department of Neurological Surgery, University of Florida College of Medicine, Gainesville, Florida, USA
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  • Dominique Coco MD,

    1. Department of Pathology, Immunology and Laboratory Medicine, University of Florida College of Medicine, Gainesville, Florida, USA
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  • Anthony T. Yachnis MD,

    1. Department of Pathology, Immunology and Laboratory Medicine, University of Florida College of Medicine, Gainesville, Florida, USA
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  • Hubert H. Fernandez MD

    1. Department of Neurology, Movement Disorders Center, University of Florida College of Medicine, Gainesville, Florida, USA
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Abstract

Chorea is a rare manifestation of paraneoplastic disease and is associated with CV2/CRMP-5 antibodies. Obsessive–compulsive disorder and large-scale white matter abnormalities on MRI have not been previously reported in association with these antibodies. We report on a case of CV2 paraneoplastic syndrome with obsessive–compulsive behavior preceding the motor manifestations of chorea with associated leukoencephalopathy on MRI. The literature on paraneoplastic chorea is reviewed. © 2005 Movement Disorder Society

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