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Keywords:

  • sporadic idiopathic Parkinson's disease;
  • motor neuron disease;
  • Lewy bodies;
  • argyrophilic grain disease

Abstract

We report on two cases of sporadic idiopathic Parkinson's disease with motor neuron disease co-occurring in the same individuals. Pathological analysis revealed the presence of Lewy bodies in brainstem nuclei and basal forebrain consistent with Lewy body disease (LBD), as well as motor neuron degeneration and argyrophilic grain disease. We compared our two cases to all previously published pathological cases of combined LBD and motor neuron degeneration. © 2005 Movement Disorder Society