Acute pathological laughter

Authors

  • Darin T. Okuda MD,

    Corresponding author
    1. Division of Neurology, University of California at San Francisco, San Francisco, California, USA
    2. Multiple Sclerosis Center, University of California at San Francisco, San Francisco, California, USA
    • Multiple Sclerosis Center, Division of Neurology, University of California at San Francisco, 350 Parnassus Avenue, Suite 908, San Francisco, CA 94117
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  • Abraham S.C. Chyung MD, PhD,

    1. Division of Neurology, University of California at San Francisco, San Francisco, California, USA
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  • Cynthia T. Chin MD,

    1. Division of Neuroradiology, University of California at San Francisco, San Francisco, California, USA
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  • Emmanuelle Waubant MD

    1. Division of Neurology, University of California at San Francisco, San Francisco, California, USA
    2. Multiple Sclerosis Center, University of California at San Francisco, San Francisco, California, USA
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Abstract

Pseudobulbar affect is a condition characterized by uncontrollable episodes of inappropriate laughing or crying that are disproportionate and discordant to the situation at hand. We report on a 16-year-old woman presenting with acute pathological laughter in the context of CNS demyelinating disease. Brain MRI scans fortuitously obtained before and after the onset of this symptom demonstrated acute gadolinium-enhancing lesions in the cerebral peduncles. The etiology of this condition remains theoretical; however, the results here provide further insights into the pathways of emotional control. © 2005 Movement Disorder Society

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