Brief Report

Quantification of acetogenins in Annona muricata linked to atypical parkinsonism in guadeloupe

  1. Pierre Champy PharmD, PhD1,
  2. Alice Melot PharmD1,
  3. Vincent Guérineau Eng2,
  4. Christophe Gleye PharmD, PhD1,
  5. Djibril Fall PharmD, PhD1,3,
  6. Gunter U. Höglinger MD, PhD4,
  7. Merle Ruberg PhD4,*,
  8. Annie Lannuzel MD, PhD4,5,
  9. Olivier Laprévote PharmD, PhD2,
  10. Alain Laurens PharmD, PhD1,
  11. Reynald Hocquemiller PharmD, PhD1

Article first published online: 2 AUG 2005

DOI: 10.1002/mds.20632

Issue

Movement Disorders

Movement Disorders

Volume 20, Issue 12, pages 1629–1633, December 2005

Additional Information

How to Cite

Champy, P., Melot, A., Guérineau Eng, V., Gleye, C., Fall, D., Höglinger, G. U., Ruberg, M., Lannuzel, A., Laprévote, O., Laurens, A. and Hocquemiller, R. (2005), Quantification of acetogenins in Annona muricata linked to atypical parkinsonism in guadeloupe. Mov. Disord., 20: 1629–1633. doi: 10.1002/mds.20632

Author Information

  1. 1

    Laboratory of Pharmacognosy, UMR 8076 Centre National de la Recherche Scientifique (CNRS) BioCIS, Faculté de Pharmacie Paris XI, Châtenay-Malabry, France

  2. 2

    Laboratory of Mass Spectrometry, Institut de Chimie des Substances Naturelles, Centre National de la Recherche Scientifique (CNRS) Gif-sur-Yvette, France

  3. 3

    Laboratory of Therapeutic Chemistry, Faculté de Pharmacie, Université Cheikh Anta Diop, Dakar, Senegal

  4. 4

    Institut National de la Santé et de la Recherche Médicale (INSERM) U679, Experimental Neurology and Therapeutics, Paris, France

  5. 5

    Department of Neurology, Centre Hospitalier Universitaire (CHU) Antilles-Guyane, Pointe-à-Pitre, Guadeloupe, France

*INSERM U679 (formerly U289), Hôpital de la Salpêtrière, 47 Bd de l'Hôpital, 75013 Paris, France

Publication History

  1. Issue published online: 31 OCT 2005
  2. Article first published online: 2 AUG 2005
  3. Manuscript Accepted: 12 MAR 2005
  4. Manuscript Received: 27 JAN 2005

Funded by

  • Centre National de Recherche Scientifique (CNRS)

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Keywords:

  • acetogenin;
  • annonacin;
  • neurotoxin;
  • mitochondria;
  • Parkinson's disease;
  • MALDI MS

Abstract

Atypical parkinsonism in Guadeloupe has been associated with the consumption of fruit and infusions or decoctions prepared from leaves of Annona muricata L. (Annonaceae), which contains annonaceous acetogenins, lipophilic inhibitors of complex I of the mitochondrial respiratory chain. We have determined the concentrations of annonacin, the major acetogenin in A. muricata, in extracts of fruit and leaves by matrix-assisted laser desorption-ionization mass spectrometry. An average fruit is estimated to contain about 15 mg of annonacin, a can of commercial nectar 36 mg, and a cup of infusion or decoction 140 μg. As an indication of its potential toxicity, an adult who consumes one fruit or can of nectar a day is estimated to ingest over 1 year the amount of annonacin that induced brain lesions in rats receiving purified annonacin by intravenous infusion. © 2005 Movement Disorder Society

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