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Tegaserod (Zelnorm) for the treatment of constipation in Parkinson's disease

Authors

  • Kelly L. Sullivan MSPH,

    Corresponding author
    1. Parkinson's Disease and Movement Disorders Center, NPF Center of Excellence, University of South Florida, Tampa, Florida, USA
    2. Department of Neurology, University of South Florida, Tampa, Florida, USA
    • Parkinson's Disease and Movement Disorders Center, Department of Neurology, University of South Florida, MDC 55, 12901 Bruce B. Downs Boulevard, Tampa, FL 33612
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  • Joseph F. Staffetti MD,

    1. Regional Medical Center–Bayonet Point, Hudson, Florida, USA
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  • Robert A. Hauser MD,

    1. Parkinson's Disease and Movement Disorders Center, NPF Center of Excellence, University of South Florida, Tampa, Florida, USA
    2. Department of Neurology, University of South Florida, Tampa, Florida, USA
    3. Center of Excellence for Aging and Brain Repair, University of South Florida, Tampa, Florida, USA
    4. Department of Pharmacology and Experimental Therapeutics, University of South Florida, Tampa, Florida, USA
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  • Peter B. Dunne MD,

    1. Department of Neurology, University of South Florida, Tampa, Florida, USA
    2. James A. Haley Veterans Administration Hospital, University of South Florida, Tampa, Florida, USA
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  • Theresa A. Zesiewicz MD

    1. Parkinson's Disease and Movement Disorders Center, NPF Center of Excellence, University of South Florida, Tampa, Florida, USA
    2. Department of Neurology, University of South Florida, Tampa, Florida, USA
    3. Center of Excellence for Aging and Brain Repair, University of South Florida, Tampa, Florida, USA
    4. James A. Haley Veterans Administration Hospital, University of South Florida, Tampa, Florida, USA
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Abstract

We performed a double-blind randomized placebo-controlled pilot study to determine the efficacy of tegaserod (Zelnorm) in treating constipation in 15 patients with Parkinson's disease (PD). There was a trend for improvement in the Subject's Global Assessment (SGA) of satisfaction with bowel habits (NS) and the total SGA (including abdominal discomfort, bothersome constipation, and satisfaction; NS). © 2005 Movement Disorder Society

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