REM sleep behavior disorder, hallucinations, and cognitive impairment in Parkinson's disease

Authors

  • Elena Sinforiani MD,

    Corresponding author
    1. Laboratory of Neuropsychology, IRCCS C. Mondino Institute of Neurology, Pavia, Italy
    • IRCCS C. Mondino, Via Ferrata 6, 27100 Pavia, Italy

    Search for more papers by this author
  • Roberta Zangaglia MD,

    1. Parkinson's Disease and Movement Disorders Unit, Istituto di Ricovero e Cura a Carattere Scientifico C. Mondino Institute of Neurology, Pavia, Italy
    Search for more papers by this author
  • Raffaele Manni MD,

    1. Sleep Medicine Unit, Istituto di Ricovero e Cura a Carattere Scientifico C. Mondino Institute of Neurology, Pavia, Italy
    Search for more papers by this author
  • Silvano Cristina MD,

    1. Parkinson's Disease and Movement Disorders Unit, Istituto di Ricovero e Cura a Carattere Scientifico C. Mondino Institute of Neurology, Pavia, Italy
    Search for more papers by this author
  • Enrico Marchioni MD,

    1. Laboratory of Epidemiology and Statistics, Istituto di Ricovero e Cura a Carattere Scientifico C. Mondino Institute of Neurology, Pavia, Italy
    Search for more papers by this author
  • Giuseppe Nappi MD,

    1. Department of Neurology and Otolaryngology, University La Sapienza, Rome, Italy
    2. IRCCS C. Mondino Institute of Neurology, Pavia, Italy
    Search for more papers by this author
  • Francesca Mancini MD, PhD,

    1. Parkinson's Disease and Movement Disorders Unit, Istituto di Ricovero e Cura a Carattere Scientifico C. Mondino Institute of Neurology, Pavia, Italy
    Search for more papers by this author
  • Claudio Pacchetti MD

    1. Parkinson's Disease and Movement Disorders Unit, Istituto di Ricovero e Cura a Carattere Scientifico C. Mondino Institute of Neurology, Pavia, Italy
    Search for more papers by this author

Abstract

The objective of this study was to evaluate the relationship between REM sleep behavior disorder (RBD), hallucinations, and cognitive impairment in Parkinson's disease (PD). One hundred and ten PD patients, divided into three groups (without RBD or hallucinations; with RBD but no hallucinations; with RBD and hallucinations), were submitted to neuropsychological evaluation. The group without RBD and hallucinations showed normal neuropsychological tests when compared to normal controls. The group with hallucinations was characterized by a more severe cognitive impairment affecting both short- and long-term memory, logical abilities, and frontal functions, while the RBD-only group presented frontal impairment. The hypothesis that RBD in PD can be considered a risk factor not only of the hallucinations but also of more severe and diffuse cognitive abnormalities needs to be strengthened through a longitudinal evaluation. © 2005 Movement Disorder Society

Ancillary