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Hereditary spastic paraplegia associated with dopa-responsive parkinsonism



A 47-year-old patient with hereditary spastic paraplegia and parkinsonian features is reported. Treatment with levodopa led to marked improvement in his neurological status and quality of life. However, several years later he developed motor fluctuations and dyskinesias. The latter promptly remitted with amantadine treatment. © 2006 Movement Disorder Society