The first two authors contributed equally to this work.
Deep brain stimulation in Tourette's syndrome: Two targets?
Article first published online: 6 FEB 2006
Copyright © 2006 Movement Disorder Society
Volume 21, Issue 5, pages 709–713, May 2006
How to Cite
Ackermans, L., Temel, Y., Cath, D., van der Linden, C., Bruggeman, R., Kleijer, M., Nederveen, P., Schruers, K., Colle, H., Tijssen, M. A.J. and Visser-Vandewalle, V. (2006), Deep brain stimulation in Tourette's syndrome: Two targets?. Mov. Disord., 21: 709–713. doi: 10.1002/mds.20816
- Issue published online: 4 MAY 2006
- Article first published online: 6 FEB 2006
- Manuscript Accepted: 7 SEP 2005
- Manuscript Revised: 8 AUG 2005
- Manuscript Received: 27 JAN 2005
- Tourette's syndrome;
- deep brain stimulation;
- globus pallidus internus
In this report, we describe the effects of bilateral thalamic stimulation in one patient and of bilateral pallidal stimulation in another patient. Both patients suffered from intractable Tourette’s syndrome (TS). Any conservative treatment had failed or had been stopped because of unbearable side effects in the 2 patients. In both cases, there was no comorbidity except for associated behavioral symptoms (compulsions). Electrodes were implanted at the level of the medial part of the thalamus (centromedian nucleus, the substantia periventricularis, and the nucleus ventro-oralis internus) in one patient and in the posteroventral part of the globus pallidus internus (GPi) in the other patient. In both cases, deep brain stimulation (DBS) resulted in a substantial reduction of tics and compulsions. These data show that bilateral DBS of the thalamus as well as of the GPi can have a good effect on tics and behavioral symptoms in patients suffering from intractable TS. © 2006 Movement Disorder Society