• Please log in or register to access this feature.

Brief Report

Topography of putaminal degeneration in multiple system atrophy: A diffusion magnetic resonance study

  1. Klaus Seppi MD1,†,
  2. Michael F.H. Schocke MD2,†,
  3. Kathrin Prennschuetz-Schuetzenau PhD1,
  4. Katherina J. Mair MD1,
  5. Regina Esterhammer MD2,
  6. Christian Kremser PhD2,
  7. Armin Muigg MD1,
  8. Christoph Scherfler MD1,
  9. Werner Jaschke MD2,
  10. Gregor K. Wenning MD, PhD1,
  11. Werner Poewe MD1,*

Article first published online: 14 MAR 2006

DOI: 10.1002/mds.20843

Issue

Movement Disorders

Movement Disorders

Volume 21, Issue 6, pages 847–852, 6 June 2006

Additional Information

How to Cite

Seppi, K., Schocke, M. F.H., Prennschuetz-Schuetzenau, K., Mair, K. J., Esterhammer, R., Kremser, C., Muigg, A., Scherfler, C., Jaschke, W., Wenning, G. K. and Poewe, W. (2006), Topography of putaminal degeneration in multiple system atrophy: A diffusion magnetic resonance study. Mov. Disord., 21: 847–852. doi: 10.1002/mds.20843

Author Information

  1. 1

    Department of Neurology, Innsbruck Medical University, Austria

  2. 2

    Department of Radiology 1, Innsbruck Medical University, Austria

  1. †

    Drs. Seppi and Schocke contributed equally to this work.

*Department of Neurology, Innsbruck Medical University, Innsbruck, Austria

  1. †

    Drs. Seppi and Schocke contributed equally to this work.

Publication History

  1. Issue published online: 6 JUN 2006
  2. Article first published online: 14 MAR 2006
  3. Manuscript Accepted: 4 OCT 2005
  4. Manuscript Revised: 13 SEP 2005
  5. Manuscript Received: 18 FEB 2005

Funded by

  • Austrian Federal Ministry of Science and Transport. Grant Number: GZ 70038/2 PR 4/98

SEARCH

SEARCH BY CITATION

ARTICLE TOOLS

View Full Article (HTML) Get PDF (135K)

Keywords:

  • multiple system atrophy;
  • putamen;
  • magnetic resonance imaging;
  • diffusion-weighted imaging

Abstract

There is neuropathologic evidence that, in early stages of the Parkinson variant of multiple system atrophy (MSA-P), the putamen shows a distinct topographical pathology affecting predominantly the dorsolateral and caudal regions while leaving the rostral to midparts almost intact. We investigated the topographic profile of putaminal degeneration in MSA-P patients in vivo by means of diffusion-weighted imaging (DWI), which has been shown to reveal abnormalities in the basal ganglia of patients with MSA-P compared to patients with PD and healthy controls. For this purpose, regional trace of the diffusion tensor (rTrace(D)) values were determined in the entire, anterior, and posterior putamen in 15 patients with probable MSA-P, in 20 patients with PD, and in 11 healthy volunteers matched for age and disease duration. MSA-P patients had significantly higher rTrace(D) values in entire, anterior, and posterior putamen compared to both controls and PD patients. Trace(D) values were significantly higher in the posterior compared to the anterior putamen in the MSA-P group. There were no significant differences between posterior and anterior putamen in both the control and PD group. Our study demonstrates prominent involvement of the posterior putamen in early disease stages of MSA-P in vivo by assessing putaminal diffusivity with the help of DWI. © 2006 Movement Disorder Society

View Full Article (HTML) Get PDF (135K)