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New developments of brain imaging for Parkinson's disease and related disorders†

  1. Paola Piccini MD, PhD*,
  2. David J. Brooks MD, DSc

Article first published online: 27 JUL 2006

DOI: 10.1002/mds.20845

Issue

Movement Disorders

Movement Disorders

Volume 21, Issue 12, pages 2035–2041, December 2006

Additional Information

How to Cite

Piccini, P. and Brooks, D. J. (2006), New developments of brain imaging for Parkinson's disease and related disorders. Mov. Disord., 21: 2035–2041. doi: 10.1002/mds.20845

Author Information

  1. MRC Clinical Sciences Centre and Division of Neuroscience and Mental Health, Imperial College, Hammersmith Hospital, London, United Kingdom

*MRC Clinical Sciences Centre and Division of Neuroscience, Faculty of Medicine, Imperial College, Hammersmith Hospital, Du Cane Road, London W12 ONN, United Kingdom

  1. †

    This article is part of the journal's CME program. The CME form for this article can be found at http://www.movementdisorders.org/education/activities.shtml/#journal

Publication History

  1. Issue published online: 19 DEC 2006
  2. Article first published online: 27 JUL 2006
  3. Manuscript Accepted: 10 SEP 2005
  4. Manuscript Revised: 8 SEP 2005
  5. Manuscript Received: 15 APR 2005

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Keywords:

  • functional imaging;
  • Parkinson's disease;
  • movement disorders

Abstract

Parkinson's disease (PD) and related disorders are subcortical degenerations targeting the nigrostriatal dopaminergic system and basal ganglia. Traditionally, MRI has been used to detect structural and positron emission tomography and single emission computed tomography functional neurochemical and metabolic changes associated with these disorders. Recently, advances in diffusion-weighted MRI, ultrasonography, and radiotracer-based imaging have yielded greater sensitivity for revealing structural change and allowed detection of changes in brain dopamine levels after levodopa and during behavioral tasks. This review focuses on these recent advances in neuroimaging technology and their use for the diagnosis and assessment of PD and other parkinsonian disorders. © 2006 Movement Disorder Society

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