Increase in body weight after pramipexole treatment in Parkinson's disease

Authors

  • Hatice Kumru MD,

    1. Neurology Service, Hospital Clínic de Barcelona and Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Universitat de Barcelona, Barcelona, Spain
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  • Joan Santamaria MD,

    Corresponding author
    1. Neurology Service, Hospital Clínic de Barcelona and Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Universitat de Barcelona, Barcelona, Spain
    • Neurology Service, Hospital Clinic de Barcelona, c/ Villarroel, 170, Barcelona, 08036 Spain
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  • Francesc Valldeoriola MD,

    1. Neurology Service, Hospital Clínic de Barcelona and Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Universitat de Barcelona, Barcelona, Spain
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  • Maria J. Marti MD,

    1. Neurology Service, Hospital Clínic de Barcelona and Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Universitat de Barcelona, Barcelona, Spain
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  • Eduardo Tolosa MD

    1. Neurology Service, Hospital Clínic de Barcelona and Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Universitat de Barcelona, Barcelona, Spain
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Abstract

Body weight changes occur during the clinical course of Parkinson's disease (PD) and with surgical treatment, but the effect of dopaminergic treatment on weight is unknown. Body mass index (BMI), Hamilton depression scale score (HDS), and Unified Parkinson's Disease Rating Scale III (UPRS-III) were measured before and 3 months after starting pramipexole in 28 PD patients. Pramipexole produced a significant weight increase, as well as motor and mood improvement (P <0.001). HDS and BMI changes were mildly related (P = 0.05). A direct effect of pramipexole on limbic D3 receptors involved in the control of feeding may be responsible for weight gain in PD. © 2006 Movement Disorder Society

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