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Keywords:

  • essential tremor;
  • pregabalin;
  • Lyrica;
  • gamma-aminobutyric acid;
  • tremor

Abstract

We report on 2 essential tremor patients who experienced marked improvement in upper extremity tremor with the use of pregabalin (Lyrica, PGB). On PGB 200 mg/day, tremor amplitude was reduced by at least 40% in the worst affected hand in both patients as measured by accelerometry. Both patients also reported moderate reduction in tremor on the Clinical Global Impression Scale, and Fahn–Tolosa–Marin Part I scores were markedly improved. © 2006 Movement Disorder Society