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Pregabalin (Lyrica) in the treatment of essential tremor

Authors

  • Theresa A. Zesiewicz MD, FAAN,

    Corresponding author
    1. Parkinson's Disease and Movement Disorders Center, Department of Neurology, Department of Molecular Therapeutics, Neuroscience Program, National Parkinson's Foundation Center of Excellence, Department of Psychiatry, University of South Florida, Tampa, Florida, USA
    • University of South Florida, 12901 Bruce B. Downs Blvd., MDC Box 55, Tampa, FL 33612
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  • Christopher L. Ward LMT,

    1. Parkinson's Disease and Movement Disorders Center, Department of Neurology, Department of Molecular Therapeutics, Neuroscience Program, National Parkinson's Foundation Center of Excellence, Department of Psychiatry, University of South Florida, Tampa, Florida, USA
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  • Robert A. Hauser MD,

    1. Parkinson's Disease and Movement Disorders Center, Department of Neurology, Department of Molecular Therapeutics, Neuroscience Program, National Parkinson's Foundation Center of Excellence, Department of Psychiatry, University of South Florida, Tampa, Florida, USA
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  • Jessica A. Pease Campbell MD,

    1. Parkinson's Disease and Movement Disorders Center, Department of Neurology, Department of Molecular Therapeutics, Neuroscience Program, National Parkinson's Foundation Center of Excellence, Department of Psychiatry, University of South Florida, Tampa, Florida, USA
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  • Kelly L. Sullivan MSPH

    1. Parkinson's Disease and Movement Disorders Center, Department of Neurology, Department of Molecular Therapeutics, Neuroscience Program, National Parkinson's Foundation Center of Excellence, Department of Psychiatry, University of South Florida, Tampa, Florida, USA
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Abstract

We report on 2 essential tremor patients who experienced marked improvement in upper extremity tremor with the use of pregabalin (Lyrica, PGB). On PGB 200 mg/day, tremor amplitude was reduced by at least 40% in the worst affected hand in both patients as measured by accelerometry. Both patients also reported moderate reduction in tremor on the Clinical Global Impression Scale, and Fahn–Tolosa–Marin Part I scores were markedly improved. © 2006 Movement Disorder Society

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