Mood stability during acute stimulator challenge in Parkinson's disease patients under long-term treatment with subthalamic deep brain stimulation

Authors

  • Alexandre Berney MD,

    1. Department of Psychiatry, McGill University, Montreal, Canada
    2. Department of Psychiatry, Lausanne University, Switzerland
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  • Michel Panisset MD,

    Corresponding author
    1. Departments of Neurology and Neurosurgery, McGill University, Montreal, Canada
    2. University of Montreal Health Centre (CHUM), Hôtel-Dieu Pavillon, Montreal, Canada
    • André-Barbeau Movement Disorder Unit, Hôtel-Dieu du CHUM, suite 7561, 3840 rue St-Urbain, Montréal, Québec, Canada
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  • Abbas F. Sadikot MD, PhD,

    1. Departments of Neurology and Neurosurgery, McGill University, Montreal, Canada
    2. University of Montreal Health Centre (CHUM), Hôtel-Dieu Pavillon, Montreal, Canada
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  • Alain Ptito PhD,

    1. Departments of Neurology and Neurosurgery, McGill University, Montreal, Canada
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  • Alain Dagher MD,

    1. Departments of Neurology and Neurosurgery, McGill University, Montreal, Canada
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  • Maria Fraraccio MSc,

    1. Departments of Neurology and Neurosurgery, McGill University, Montreal, Canada
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  • Ghislaine Savard MD,

    1. Department of Psychiatry, McGill University, Montreal, Canada
    2. Departments of Neurology and Neurosurgery, McGill University, Montreal, Canada
    3. University of Montreal Health Centre (CHUM), Hôtel-Dieu Pavillon, Montreal, Canada
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  • Marc Pell PhD,

    1. McGill School of Communication Sciences and Disorders, McGill University, Montreal, Canada
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  • Chawki Benkelfat MD, DERBH

    1. Department of Psychiatry, McGill University, Montreal, Canada
    2. Departments of Neurology and Neurosurgery, McGill University, Montreal, Canada
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Abstract

Acute and chronic behavioral effects of subthalamic stimulation (STN-DBS) for Parkinson's disease (PD) are reported in the literature. As the technique is relatively new, few systematic studies on the behavioral effects in long-term treated patients are available. To further study the putative effects of STN-DBS on mood and emotional processing, 15 consecutive PD patients under STN-DBS for at least 1 year, were tested ON and OFF stimulation while on or off medication, with instruments sensitive to short-term changes in mood and in emotional discrimination. After acute changes in experimental conditions, mood core dimensions (depression, elation, anxiety) and emotion discrimination processing remained remarkably stable, in the face of significant motor changes. Acute stimulator challenge in long-term STN-DBS–treated PD patients does not appear to provoke clinically relevant mood effects. © 2007 Movement Disorder Society

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