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Local field potentials and oscillatory activity of the internal globus pallidus in myoclonus–dystonia

Authors

  • Elisabeth M.J. Foncke MD,

    1. Department of Neurology and Clinical Neurophysiology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
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  • Lo J. Bour PhD,

    1. Department of Neurology and Clinical Neurophysiology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
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  • Johannes D. Speelman MD, PhD,

    1. Department of Neurology and Clinical Neurophysiology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
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  • Johannes H.T.M. Koelman MD, PhD,

    1. Department of Neurology and Clinical Neurophysiology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
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  • Marina A.J. Tijssen MD, PhD

    Corresponding author
    1. Department of Neurology and Clinical Neurophysiology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    • Department of Neurology H2-222, Academic Medical Center, P.O. Box 22660, 1100 DD Amsterdam, The Netherlands
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Abstract

The pathophysiology of myoclonus–dystonia (M–D), an autosomal dominantly inherited movement disorder characterized by myoclonic jerks and dystonic contractions, is largely unknown. In the present study, local field potential (LFP) activities in the globus pallidus internus (GPi) from two genetically proven M–D patients are investigated. Coherence analysis between GPi LFP activity and electromyographic muscle activity (EMG) and synchronization of GPi neuronal activity using event-related spectral perturbation (ERSP) in a go–no-go paradigm were studied. Significant increased coherence in the 3 to 15 Hz frequency band was detected between GPi LFP activity and several muscles, with the LFP leading the muscles. The ERSP analysis revealed synchronization in the 3 to 15 Hz frequency band within the GPi before the imperative cue of the go–no-go task and desynchronization in the same band after the cue. The LFP recordings of the GPi in M–D show that the low-frequency band previously described in dystonia is also involved in the dystonia plus syndrome M–D. The 3 to 15 Hz synchronization in the go–no-go paradigm has not been described previously and may point to the existence of (myoclonus–)dystonia specific oscillatory activity in the GPi. © 2006 Movement Disorder Society

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