Research Article

Rat model of Parkinson's disease with bilateral motor abnormalities, reversible with levodopa, and dyskinesias

  1. Vincent Paillé PhD1,2,
  2. Vincent Henry MS1,2,
  3. Laurent Lescaudron PhD1,3,
  4. Philippe Brachet PhD1,2,
  5. Philippe Damier MD, PhD1,4,*

Article first published online: 17 JAN 2007

DOI: 10.1002/mds.21308

Issue

Movement Disorders

Movement Disorders

Volume 22, Issue 4, pages 533–539, 15 March 2007

Additional Information

How to Cite

Paillé, V., Henry, V., Lescaudron, L., Brachet, P. and Damier, P. (2007), Rat model of Parkinson's disease with bilateral motor abnormalities, reversible with levodopa, and dyskinesias. Mov. Disord., 22: 533–539. doi: 10.1002/mds.21308

Author Information

  1. 1

    INSERM, UMR 643 and Institut de Transplantation et de Recherche en Transplantation, CHU, Nantes, France

  2. 2

    UFR de Médecine,Université de Nantes, Nantes, France

  3. 3

    UFR des Sciences et des Techniques,Université de Nantes, Nantes, France

  4. 4

    CHU Nantes, Clinique Neurologique and Centre d'Investigation Clinique, Nantes, France

*Clinique Neurologique, Hôpital Guillaume et René Laënnec, Boulevard Jacques Monod, F-44093 Nantes Cedex 01, France

Publication History

  1. Issue published online: 27 MAR 2007
  2. Article first published online: 17 JAN 2007
  3. Manuscript Accepted: 4 OCT 2006
  4. Manuscript Revised: 2 OCT 2006
  5. Manuscript Received: 18 JUN 2006

Funded by

  • INSERM (AVENIR 2001)
  • Association de parkinsoniens de Loire-Atlantique (ADPLA)

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This article contains Supplementary Video, available online at http://www.interscience.wiley.com/jpages/0885-3185/suppmat

FilenameFormatSizeDescription
jws-mds.21308.mpg13552KForelimb abnormal motor behavior following bilateral lesion assessed by a modified version of the stepping test and improvement of performance during L-dopa treatment:Segment 1. Stepping test performed by a sham-lesioned rat (6th day of L-dopa treatment).Segment 2. Stepping test performed by a rat with bilateral partial lesion (before L-dopa treatment).Segment 3. Stepping test performed by the same lesioned-rat during L-dopa treatment (6th day of treatment).Bilateral dyskinesiasSegment 4. Rat with bilateral 6-OHDA lesion presenting bilateral forelimb dyskinesias with unilateral dystonia following 6 days of L-dopa treatment.Segment 5. Orolingual dyskinesias in a 6-OHDA-lesioned rat.Segment 6. Unilateral forelimb dyskinesias in a 6-OHDA-lesioned rat.

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