Get access

Higher nigrostriatal dopamine neuron loss in early than late onset Parkinson's disease?—A [99mTc]-TRODAT-1 SPECT study

Authors

  • Ming Chi Shih MD, PhD,

    Corresponding author
    1. Laboratório Interdiciplinar de Neuroimagem e Cognição (LiNC), Universidade Federal de São Paulo, Sao Paulo, Brazil
    2. Instituto Israelita de Ensino e Pesquisa Albert Einstein (IIEP-HIAE), Sao Paulo, Brazil
    • Laboratório de Neuroimagem e Cognição (LiNC), Department of Psychiatry, Federal University of Sao Paulo, Rua Dr Bacelar, 334, CEP 04026-001, Sao Paulo-SP, Brazil
    Search for more papers by this author
  • Luiz Augusto Franco de Andrade MD, PhD,

    1. Instituto Israelita de Ensino e Pesquisa Albert Einstein (IIEP-HIAE), Sao Paulo, Brazil
    Search for more papers by this author
  • Edson Amaro Jr MD, PhD,

    1. Instituto Israelita de Ensino e Pesquisa Albert Einstein (IIEP-HIAE), Sao Paulo, Brazil
    2. Imaging Department, Hospital Israelita Albert Einstein, Sao Paulo, Brazil
    Search for more papers by this author
  • Andre Carvalho Felicio MD,

    1. Department of Neurology, Universidade Federal de São Paulo, Sao Paulo, Brazil
    Search for more papers by this author
  • Henrique Ballalai Ferraz MD, PhD,

    1. Department of Neurology, Universidade Federal de São Paulo, Sao Paulo, Brazil
    Search for more papers by this author
  • Jairo Wagner MD,

    1. Imaging Department, Hospital Israelita Albert Einstein, Sao Paulo, Brazil
    Search for more papers by this author
  • Marcelo Queiroz Hoexter MD,

    1. Laboratório Interdiciplinar de Neuroimagem e Cognição (LiNC), Universidade Federal de São Paulo, Sao Paulo, Brazil
    Search for more papers by this author
  • Li Fu Lin PhD,

    1. Institute of Nuclear Energy Research (INER), Long-Tan, Taiwan, Republic of China
    Search for more papers by this author
  • Ying Kai Fu PhD,

    1. Institute of Nuclear Energy Research (INER), Long-Tan, Taiwan, Republic of China
    Search for more papers by this author
  • Jair Jesus Mari MD, PhD,

    1. Department of Psychiatry, Universidade Federal de São Paulo, Sao Paulo, Brazil
    Search for more papers by this author
  • Sergio Tufik MD, PhD,

    1. Department of Psychobiology, Universidade Federal de São Paulo, Sao Paulo, Brazil
    Search for more papers by this author
  • Rodrigo Affonseca Bressan MD, PhD

    Corresponding author
    1. Laboratório Interdiciplinar de Neuroimagem e Cognição (LiNC), Universidade Federal de São Paulo, Sao Paulo, Brazil
    2. Instituto Israelita de Ensino e Pesquisa Albert Einstein (IIEP-HIAE), Sao Paulo, Brazil
    • Laboratório de Neuroimagem e Cognição (LiNC), Department of Psychiatry, Federal University of Sao Paulo, Rua Dr Bacelar, 334, CEP 04026-001, Sao Paulo-SP, Brazil
    Search for more papers by this author

Abstract

Early-onset Parkinson's disease (EOPD) is distinct from the classic late-onset PD (LOPD) because of its slower disease progression. The aim of this study was to compare dopamine neuronal loss in EOPD with that of LOPD with the same disease duration, through dopamine transporter (DAT) estimation. Fourteen patients, seven EOPD (<50 years) and seven LOPD, matched for disease duration were scanned with [99mTc]-TRODAT-1-SPECT (INER-Taiwan), and were assessed with standard PD scales. EOPD patients had 34% lower striatal DAT binding potential (BP) compared with that of LOPD patients (BP = 0.29 ± 0.12, BP = 0.44 ± 0.12, P < 0.02) with similar PD severity. These results suggest that EOPD patients have greater dopamine density loss than LOPD patients without motor-symptom worsening. © 2007 Movement Disorder Society

Ancillary