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Apolipoprotein E ε4 allele is associated with Parkinson disease risk in a Mexican Mestizo population

Authors

  • Marisol López PhD,

    1. Department of Biological Systems, Universidad Autónoma Metropolitana Xochimilco, Mexico City, Mexico
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  • Jorge Guerrero BSc,

    1. Department of Neurogenetics and Molecular Biology, Instituto Nacional de Neurología y Neurocirugía Manuel Velasco Suárez, Mexico City, Mexico
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  • Petra Yescas MSc,

    1. Department of Neurogenetics and Molecular Biology, Instituto Nacional de Neurología y Neurocirugía Manuel Velasco Suárez, Mexico City, Mexico
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  • Marie-Catherine Boll MD, PhD,

    1. Division of Neurology, Instituto Nacional de Neurología y Neurocirugía Manuel Velasco Suárez, Mexico City, Mexico
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  • Itziar Familiar MD,

    1. Department of Neurogenetics and Molecular Biology, Instituto Nacional de Neurología y Neurocirugía Manuel Velasco Suárez, Mexico City, Mexico
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  • Adriana Ochoa MSc,

    1. Department of Neurogenetics and Molecular Biology, Instituto Nacional de Neurología y Neurocirugía Manuel Velasco Suárez, Mexico City, Mexico
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  • Astrid Rasmussen MD, PhD,

    1. Department of Neurogenetics and Molecular Biology, Instituto Nacional de Neurología y Neurocirugía Manuel Velasco Suárez, Mexico City, Mexico
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  • María Elisa Alonso MD

    Corresponding author
    1. Department of Neurogenetics and Molecular Biology, Instituto Nacional de Neurología y Neurocirugía Manuel Velasco Suárez, Mexico City, Mexico
    • Instituto Nacional de Neurología y Neurocirugía Manuel Velasco Suárez, Departamento de Neurogenética, Insurgentes Sur 3877, Colonia La Fama, Tlalpan, 14269 México D.F., Mexico
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Abstract

We investigated the association between apolipoprotein E (APOE) alleles and genotypes and Parkinson disease (PD) in 229 unrelated Mexican Mestizo PD patients and 229 controls. Results showed that both APOE-ε4 allele and APOE ε4/ε3 genotype are associated with PD (OR = 1.736, P = 0.011; OR = 1.688, P = 0.019, respectively). Mean age at onset of PD was not associated to any APOE allele or genotype, but was significantly earlier in familial PD when compared to sporadic cases (P = 0.025). © 2006 Movement Disorder Society

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