Number of children and risk of Parkinson's disease

Authors

  • Roberta Frigerio MD,

    1. Division of Epidemiology, Department of Health Sciences Research, Mayo Clinic College of Medicine, Rochester, Minnesota, USA
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    • Dr. R. Frigerio is on leave from the Department of Neuroscience and Biomedical Technologies, University of Milano-Bicocca, Monza, Italy.

  • Monique M. B. Breteler MD, PhD,

    1. Department of Epidemiology and Biostatistics, Erasmus University Medical Center, Rotterdam, The Netherlands
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  • Lonneke M. L. de Lau MD,

    1. Department of Epidemiology and Biostatistics, Erasmus University Medical Center, Rotterdam, The Netherlands
    2. Department of Neurology, Erasmus University Medical Center, Rotterdam, The Netherlands
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  • Kevin R. Sanft BS,

    1. Division of Biostatistics, Department of Health Sciences Research, Mayo Clinic College of Medicine, Rochester, Minnesota, USA
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  • James H. Bower MD,

    1. Department of Neurology, Mayo Clinic College of Medicine, Rochester, Minnesota, USA
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  • J. Eric Ahlskog PhD, MD,

    1. Department of Neurology, Mayo Clinic College of Medicine, Rochester, Minnesota, USA
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  • Brandon R. Grossardt MS,

    1. Division of Biostatistics, Department of Health Sciences Research, Mayo Clinic College of Medicine, Rochester, Minnesota, USA
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  • Mariza de Andrade PhD,

    1. Division of Biostatistics, Department of Health Sciences Research, Mayo Clinic College of Medicine, Rochester, Minnesota, USA
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  • Demetrius M. Maraganore MD,

    1. Department of Neurology, Mayo Clinic College of Medicine, Rochester, Minnesota, USA
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  • Walter A. Rocca MD, MPH

    Corresponding author
    1. Division of Epidemiology, Department of Health Sciences Research, Mayo Clinic College of Medicine, Rochester, Minnesota, USA
    2. Department of Neurology, Mayo Clinic College of Medicine, Rochester, Minnesota, USA
    • Department of Health Sciences Research, Mayo Clinic, 200 First Street SW, Rochester, MN 55905
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Abstract

We investigated the association between number of children and Parkinson's disease (PD) in two independent studies. In a case–control study, we identified all subjects who developed PD in Olmsted County, MN, from 1976 through 1995, and matched them individually by age (±1 year) and sex to population controls (193 cases and 193 controls). The replication study was a population-based cohort study of 6,341 subjects from Rotterdam, the Netherlands (2,610 men). In the Olmsted County study, men who fathered at least one child had an increased risk of PD (unadjusted OR, 2.7; 95% CI, 1.2–6.1; P = 0.02), and the risk increased with increasing number of children. The findings in women were not significant. In the Rotterdam Study, the risk of PD increased significantly with increasing number of children in men (test for linear trend, unadjusted; P = 0.04), but not in women. The findings from both studies remained consistent in direction but reduced in magnitude of the association, and lost significance after simultaneous adjustment for education, cigarette smoking, alcohol consumption, and coffee consumption. The independent replication in two distinct populations and using different epidemiologic study designs may suggest a link between the number of children and PD restricted to men. © 2007 Movement Disorder Society

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