Cell type-specific neuronal loss in the putamen of patients with multiple system atrophy

Authors

  • Kenta Sato MD,

    1. Department of Clinical Neuroscience, Institute of Health Biosciences, Graduate School of Medicine, University of Tokushima, Tokushima, Japan
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  • Ryuji Kaji MD, PhD,

    1. Department of Clinical Neuroscience, Institute of Health Biosciences, Graduate School of Medicine, University of Tokushima, Tokushima, Japan
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  • Sadayuki Matsumoto MD, PhD,

    1. Department of Neurology, Kitano Hospital and Neurological Center, Osaka, Japan
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  • Satoshi Goto MD, PhD

    Corresponding author
    1. Department of Clinical Neuroscience, Institute of Health Biosciences, Graduate School of Medicine, University of Tokushima, Tokushima, Japan
    • Department of Clinical Neuroscience, Institute of Health Biosciences, Graduate School of Medicine, University of Tokushima, Tokushima 770-8503, Japan
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Abstract

Using antibodies to calcineurin (CaN) and choline acetyltransferase (ChAT), we performed topographical and cellular immunohistochemical analysis on the posterior putamen of autopsied patients with multiple system atrophy with predominant parkinsonism (MSA-P). We document that in these patients, medium spiny neurons positive for CaN were severely depleted in the dorsolateral portion of the posterior putamen where ChAT-positive neurons are normally distributed. Our findings indicate that in patients with MSA-P, striatal neurons manifest a cell type-specific vulnerability to neurodegeneration. © 2007 Movement Disorder Society

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