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Keywords:

  • botulinum toxin;
  • freezing of gait;
  • Parkinson's disease;
  • falls

Abstract

Objective

To assess the effect on freezing of gait (FOG) of botulinum toxin type A (BTX-A) injections in advanced Parkinson's disease (PD) patients.

Method

BTX-A 150 IU or normal saline was injected into each leg's calf muscles by a blinded investigator. FOG severity was assessed at set intervals (6-month follow-up).

Results

Eleven age- and disease severity-matched PD patients with disabling FOG participated. Six patients received BTX-A and 5 received saline. No improvement was observed in either group over time. Leg weakness and falls lead to early termination.

Conclusion

BTX-A injections to the legs did not improve FOG and might increase fall risk. © 2007 Movement Disorder Society