The effect of injecting botulinum toxin type a into the calf muscles on freezing of gait in Parkinson's disease: A double blind placebo-controlled pilot study
Article first published online: 8 FEB 2007
Copyright © 2007 Movement Disorder Society
Volume 22, Issue 6, pages 880–883, 30 April 2007
How to Cite
Gurevich, T., Peretz, C., Moore, O., Weizmann, N. and Giladi, N. (2007), The effect of injecting botulinum toxin type a into the calf muscles on freezing of gait in Parkinson's disease: A double blind placebo-controlled pilot study. Mov. Disord., 22: 880–883. doi: 10.1002/mds.21396
- Issue published online: 24 APR 2007
- Article first published online: 8 FEB 2007
- Manuscript Accepted: 10 DEC 2006
- Manuscript Received: 6 DEC 2006
- Allergan, USA
- botulinum toxin;
- freezing of gait;
- Parkinson's disease;
To assess the effect on freezing of gait (FOG) of botulinum toxin type A (BTX-A) injections in advanced Parkinson's disease (PD) patients.
BTX-A 150 IU or normal saline was injected into each leg's calf muscles by a blinded investigator. FOG severity was assessed at set intervals (6-month follow-up).
Eleven age- and disease severity-matched PD patients with disabling FOG participated. Six patients received BTX-A and 5 received saline. No improvement was observed in either group over time. Leg weakness and falls lead to early termination.
BTX-A injections to the legs did not improve FOG and might increase fall risk. © 2007 Movement Disorder Society