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The effect of injecting botulinum toxin type a into the calf muscles on freezing of gait in Parkinson's disease: A double blind placebo-controlled pilot study

Authors

  • Tanya Gurevich MD,

    1. Movement Disorders Unit, Parkinson Center, Department of Neurology, Tel-Aviv Sourasky Medical Center, Tel-Aviv, Israel
    2. Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel
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  • Chava Peretz PhD,

    1. Movement Disorders Unit, Parkinson Center, Department of Neurology, Tel-Aviv Sourasky Medical Center, Tel-Aviv, Israel
    2. Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel
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  • Orna Moore RN, MA,

    1. Movement Disorders Unit, Parkinson Center, Department of Neurology, Tel-Aviv Sourasky Medical Center, Tel-Aviv, Israel
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  • Nina Weizmann MD,

    1. Movement Disorders Unit, Parkinson Center, Department of Neurology, Tel-Aviv Sourasky Medical Center, Tel-Aviv, Israel
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  • Nir Giladi MD

    Corresponding author
    1. Movement Disorders Unit, Parkinson Center, Department of Neurology, Tel-Aviv Sourasky Medical Center, Tel-Aviv, Israel
    2. Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel
    • Movement Disorders Unit, Tel Aviv Sourasky Medical Center, 6 Weizmann Street, Tel Aviv, Israel 64239
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Abstract

Objective

To assess the effect on freezing of gait (FOG) of botulinum toxin type A (BTX-A) injections in advanced Parkinson's disease (PD) patients.

Method

BTX-A 150 IU or normal saline was injected into each leg's calf muscles by a blinded investigator. FOG severity was assessed at set intervals (6-month follow-up).

Results

Eleven age- and disease severity-matched PD patients with disabling FOG participated. Six patients received BTX-A and 5 received saline. No improvement was observed in either group over time. Leg weakness and falls lead to early termination.

Conclusion

BTX-A injections to the legs did not improve FOG and might increase fall risk. © 2007 Movement Disorder Society

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